Research Article

GDF-15 As Prediction Biomarker for Cardiorenal Disease

Abstract

Background: Cardiovascular disease (CVD) leading to renal dysfunction and vice-versa is termed as cardiorenal syndrome (CRS). Objectives: The present study was designed to investigate early prediction and diagnosis of the CVD in addition to estimate some of biochemical markers and correlate between Hb concentration and kidney function test and GDF 15. Methods: The study was conducted in General Hospitals Al Sader General Teaching n the province of Al-Najaf al-Ashraf. The population of this study consisted of 75 Iraqi adults who underwent health examinations between june to January 2023. Subjects ages younger than range between (42-80) years and those with a history of CVD. The study cases are determined the age, CBC, kidney function test (urea and creatinine) and (fasting glucose and random blood sugar) in patient with CVD. Also, this study determined the level of GDF in patient with CVD and control group. Result: A total of 75 patients diagnosed as CVD admitted to our hospital were enrolled in the present study that consisting of 50 patients and 25 controls were examined. The median age was 59.92 ± 2.877 years; 100% were male, The result showed significant increase in hb and RBC 106/μl count, in patients with CVD comparison with healthy group. Patients with a higher level of WBC count were older, had a higher level of Neutrophil 103/μl, had a history of CVD (myocardial infarction and percutaneous coronary intervention or coronary artery); and had a higher rate of Creatinine (mg/dl), uremia, and hyperglycemia. Adults with CVD and higher circulating GDF-15 concentrations experienced greater mortality. Elevated GDF-15 concentration was also associated with an increased rate of heart failure. Further work is needed to elucidate the mechanisms linking these circulating biomarkers with CVD in patients with CKD. hemoglobin positively regulates the GDF. So that, there is relationship between GDF15 levels, and the risk of anemia in patient with kediny disease. GDF increase in early stage of cardiovascular disease that related to increase in Hb. So, that we suggested that the GDF is a good biomarker for predict the cardiovascular disease with high hb at disease onset.