Research Article

Association of Heat Shock Protein 20 with Biochemical and Inflammatory Markers in Osteoporosis Patients: Implications for Cardiovascular Risk

Abstract

Osteoporosis is a disease caused by decrease in bone density and deterioration of bone structure, that have different causes. the current study showed the interaction between osteoporosis and cardiovascular diseases by testing patient samples and using Heat Shock Protein 20 as a biochemical marker. This study was conducted at Al-Hussein Teaching Hospital in Karbala and some external laboratories in the Holy Karbala Governorate that have 53 cases, of which 33 were osteoporosis diagnosed with and 20 were healthy controls and the participants age ranged from 20 to 60 years. however, the result of the current study showed there is a significant increase in age and BMI, with more females and smokers in contrast to the control group. Most patients lived in urban areas, and their educational and social status varied. the result of laboratory showed decrease in levels of vitamin D3, zinc, magnesium, iron, and vitamin B12 in patients, while CRP and ALP levels were higher significant suggested possible inflammation. also, the TSH levels were increased, indicated thyroid function alterations. while the Calcium levels remained stable between groups. the heat shock protein levels were elevated in patients with osteoporosis, so that this biochemical marker associated with the disease. Conclusions: Osteoporosis patients were older, had higher BMI, and were indicated lifestyle and demographic risk factors. They had decrease in levels of vitamin D3, zinc, magnesium, iron, and B12 levels, with increased in CRP and ALP, that indicated inflammation and bone issues. the increase in TSH level may suggested dysfunction in thyroid, but the level of calcium remained stable. the high level in Heat Shock Protein 20 (HSP20) marker could reflect a protective response to inflammation and stress, potentially linking osteoporosis and cardiovascular health, warranting further research.